The Jamestown Metro Drug Task Force and the State Police Community Narcotics Enforcement Team discovered 120 bags of heroin Thursday afternoon during at an East Fourth Street apartment.
53 year-old Jose Diaz Solis and 61 year-old Juan Garcia Pinto are both facing heroin and gun charges.
Police also found a shotgun and cash.
Those arrests come a day after two other people were arrested for having heroin in the city.
Angel Cintron Fernandez and Luis Cintron were charged with criminal possession of a controlled substance after the Metro Drug Task Force and state police CNET found heroin and cash in an apartment at 718 Cherry Street.
Cintron is also charged with tampering with physical evidence.